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Dolphins vs. 49ers prediction, odds, line, spread: 2022 NFL picks, Week 13 best bets from model on 155-110 run

Two streaking division leaders will square off when the San Francisco 49ers host the Miami Dolphins in a key Week 13 NFL game on Sunday at Levi’s Stadium. The Dolphins (8-3) entered the week tied with the Bills atop the AFC East. Miami has won five games in a row, which is tied for the best active winning streak in the league. Last week, the Dolphins beat the lowly Texans, 30-15. Meanwhile, the 49ers (7-4) lead the NFC West by one game over the Seahawks. San Francisco has won four consecutive games and is coming off a 13-0 shutout of the Saints.

Kickoff is 4:05 pm ET. San Francisco is a 4-point favorite in the latest 49ers vs. Dolphins odds from Caesars Sportsbook while the over/under for total points scored is 45.5. Before you make any Dolphins vs. 49ers picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2022 NFL season on an incredible 155-110 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on 49ers vs. Dolphins and locked in their picks and NFL Week 13 predictions. You can only see the model’s picks at SportsLine. Now, here are several NFL odds and betting lines for Dolphins vs. 49ers:

  • 49ers vs. Dolphins spread: San Francisco -4
  • 49ers vs. Dolphins over/under: 45.5 points
  • 49ers vs. Dolphins money line: San Francisco -205, Miami +170
  • SF: 49ers lead the league in run defense (79.5 yards per game)
  • MIA: Tua Tagovailoa leads the league in passer rating (115.7)
  • 49ers vs. Dolphins picks: See picks here

Featured Game | San Francisco 49ers vs. Miami Dolphins

Why the 49ers can cover

San Francisco has done an excellent job at stopping the run. The 49ers are allowing opponents to rush for just 79.5 yards per game, which is the best in the league. Last week, they gave up just 63 yards on 22 attempts (2.9 yard average) to the Saints.

In addition, quarterback Jimmy Garappolo is on a roll. He has seven touchdown passes and zero interceptions over his last four games, completing 72.3% of his passes. This season, he ranks fourth in the league in touchdown-to-interception ratio (4.0) and sixth in yards per attempt (7.8). See which team to pick here.

Why the Dolphins can cover

Quarterback Tua Tagovailoa is having an NFL MVP-caliber season. The lefty gunslinger is 8-1 as a starter. He has 11 touchdown passes and zero interceptions in his last five games and leads the league in passer rating (115.7).

In addition, Bradley Chubb has bolstered the pass rush. Since joining Miami via trade, Chub has 1.5 sacks, four quarterback hits and one forced fumble in 136 defensive snaps. He has seven sacks total this season. See which team to pick here.

How to make 49ers vs. Dolphins picks

Now, the model has broken down Dolphins vs. 49ers from every angle. The model is leaning Under on the point total, but it says one side of the spread cashes in well over 50% of simulations. You can see who it is, and get the rest of the model’s NFL picks and analysis, at SportsLine.

So who wins Dolphins vs. 49ers? And which team covers well over 50% of the time? Visit SportsLine now to see which side of the Dolphins vs. 49ers spread you should jump on, all from the advanced model that is up well over $7,000, and find out.