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Rams vs. Cardinals prediction, odds, line, spread: 2022 NFL picks, Week 3 best bets from proven computer model

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Matthew Stafford and the Los Angeles Rams hit the road to take on Kyler Murray and the Arizona Cardinals at 4:25 pm ET on Sunday at State Farm Stadium in Glendale. Both teams enter the game with 1-1 records and Week 2 wins. The Rams bounced back nicely from getting blown out by the Buffalo Bills in Week 1 to knock off the Atlanta Falcons 31-27, while the Cardinals went into Las Vegas and beat the Raiders 29-23 in overtime. The Rams have won 10 of the last 11 matchups against the Cardinals.

Los Angeles is favored by 3.5 points in the latest Cardinals vs. Rams odds from Caesars Sportsbook, and the over/under is set at 48.5. Before making any Rams vs. Cardinals picks, you need to see the NFL predictions and betting advice from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Rams and just locked in his picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Cardinals vs. Rams:

  • Cardinals vs. Rams spread: Rams -3.5
  • Cardinals vs. Rams over/under: 48.5 points
  • Cardinals vs. Rams picks: See picks here

Featured Game | Arizona Cardinals vs. Los Angeles Rams

What you need to know about the Cardinals

It may have taken overtime to finish the job, but Arizona ultimately got the result it was hoping for this past Sunday with a 29-23 win over the Las Vegas Raiders. The Cardinals were down 20-0 at the end of the half, but the squad rallied to mount a spectacular comeback. No one had a standout game offensively for Arizona, but the Cardinals got scores from WR Greg Dortch and RB Darrel Williams.

The Cardinals got a gritty performance from Murray in their comeback Week 2 win over the Raiders. The 2018 Heisman Trophy winner completed 31 of 49 passes for 277 yards, 1 touchdown and one interception, to go with 28 yards and one touchdown on the ground. More importantly, though, Murray came up big for the Cardinals late in the game, leading two fourth quarter touchdown drives to send the game into overtime.

What you need to know about the Rams

Meanwhile, it wasn’t a dominant performance, but Los Angeles beat the Atlanta Falcons 31-27 this past Sunday. Los Angeles can attribute much of its success to WR Cooper Kupp, who caught 11 passes for two TDs and 108 yards.

The Rams haven’t played up to the standards set by their Super Bowl win last season, but with a substantial amount of offseason roster turnover, they will need time to gel. Stafford bounced back nicely from a below average performance in the NFL Kickoff Game to throw for 272 yards and three touchdowns in the Rams’ Week 2 win over the Falcons.

How to make Rams vs. Cardinals picks

The model has simulated Cardinals vs. Rams 10,000 times and the results are in. It is leaning Over on the point total, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model’s pick at SportsLine.

So who wins Cardinals vs. Rams? And which side of the spread has all the value? Visit SportsLine right now to find out which side of the Cardinals vs. Rams spread you should be all over, all from the model on a 139-102 roll on its top-rated NFL picks, and find out.